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 Epilim (Sodium Valproate)

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Liz Pidgley
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PostSubject: Epilim (Sodium Valproate)   Fri 02 Sep 2011, 10:08 am

Advice on sodium valproate use in women updated
30 August 2011, 9:25am MIMS


Exposure to sodium valproate in utero is known to increase the risk of neural tube defects and other malformations

Advice regarding the use of sodium valproate in women has been updated. The UK Teratology Information Service now states that:

All women of childbearing potential should be offered specialist neurological advice and given effective contraception.
If woman is planning pregnancy, treatment should be reassessed and high-dose folate supplementation provided if sodium valproate is continued.
When considering the risk-benefit balance, it is important to note that maternal seizures can also be associated with adverse foetal outcomes, including reduced placental perfusion, foetal anoxia and intrauterine death.

The updated guidance follows publication in The Lancet Neurology of data from the EURAP epilepsy and pregnancy registry, linking high maternal doses of antiepileptics to an increased risk of congenital malformations.




Liz says: I thought I would post this as there may be a rare occasion when a woman is prescribed this medication which may mask PE. If in doubt please consult your own GP or Obs. Consultant.

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Every Woman is entitled to understand what happened in her pregnancy when pre eclampsia strikes. I hope to be able to support that process.
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