Pre Eclampsia support

For Women & their families who have suffered with Pre Eclampsia, Eclampsia, HELLP syndrome, Pregnancy induced hypertension (PIH) and related conditions.
 
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 'Genes for pre-eclampsia' discovered

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Liz Pidgley
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PostSubject: 'Genes for pre-eclampsia' discovered   Thu 24 Mar 2011, 11:32 am

'Genes for pre-eclampsia' discovered

Scientists say they have identified genetic errors that appear to increase a pregnant woman's chance of getting the potentially life-threatening condition called pre-eclampsia.

Around four in every 100 women develops this problem of high blood pressure and leaky kidneys during pregnancy.

Now researchers have found faulty DNA may be to blame in some cases, PLoS Medicine journal reports.

The discovery could lead to new ways to spot and treat those at risk, they say.

The US researchers from the Washington University School of Medicine in St. Louis analysed DNA from over 300 pregnant women.

Sixty of these were otherwise healthy women who were hospitalised because they developed severe pre-eclampsia.
“It may allow us to study new treatments to prevent or delay the onset of pre-eclampsia and to know which women need closer surveillance” said Professor Basky Thilaganathan RCOG spokesman.

The remaining 250 were women who were being monitored for other health complications. Forty of these also went on to develop pre-eclampsia.

DNA analysis revealed a few genetic errors shared by five of the 60 otherwise healthy women and seven of the 40 "higher-risk pregnancy" women who developed pre-eclampsia.

The genes on which the errors were identified (MCP factor I and factor H) play a role in regulating immune response and the researchers believe this could explain their possible link to pre-eclampsia.

Scientists have suspected that problems with the immune system provoke many cases of pre-eclampsia because women with lupus and certain other autoimmune diseases - like 250 of the women in the study - have an increased risk of the disorder.

The researchers now plan to study more pregnant women and other genes to further their understanding.

Professor Basky Thilaganathan, spokesman for the Royal College of Obstetricians and Gynaecologists, said: "This work shows an association.

"At best genes like these might identify 10-15% of pre-eclampsia, so it's relative importance may not be sensational. But it may allow us to study new treatments to prevent or delay the onset of pre-eclampsia and to know which women need closer surveillance."

He said that currently the only real way to halt the condition was to deliver the baby. This can be relatively risk free if the pregnancy is nearing its natural end anyway, but can be risky if the baby is premature.

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fiveisanawfullybignumber
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PostSubject: Re: 'Genes for pre-eclampsia' discovered   Fri 25 Mar 2011, 3:53 pm

Saw this on BBc website. Turns out my mum was hospitalised when expecting me with high BP, we have a terrible immune system in our family. Mum has MS and other things.
When my daughters ever get pregnant I will be at their booking in appts, requesting consultant led care, umbillical doplers, the works!
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Docmaggoo
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PostSubject: Re: 'Genes for pre-eclampsia' discovered   Tue 12 Apr 2011, 10:22 pm

This is really interesting!

Having recently had PE myself - and having just found out my sister is pregnant - this all becomes a bit more real for us in our family, because my sis has quite severe lupus. (very difficult to control & requires some off-licence meds)

we are the most atopic and allergic family you could wish to meet.
Myself - severe allergic asthma (been on vent in ITU before), ezcema, hayfever and anaphylaxis to latex
Sis - lupus, asthma, hayfever, ezcema
Mum - 8 miscarriages before having me, the eldest (my sis's immunologist reckons probably related to an immune problem)
Dad - asthma (sent to asthmatic boarding school as child!), hayfever

.... the list goes on.

I hadn't thought of my PE as possibly being linked in with all this.

Hope my little ones inherit their dad's immune system! (plus I really hope the bf helps!)

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Liz Pidgley
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PostSubject: Re: 'Genes for pre-eclampsia' discovered   Fri 15 Apr 2011, 12:44 pm

Hi there,

Ive just answered your other post too!

But welcome to the site!

It is a really intersting piece of research but clearly it shows just how much more work there is left to do.
given all the history you describe, particularly due to Mums miscarriages, I think a blood test for 'sticky blood' might be helpful for you. You said in your last post that your sister is already on aspirin & clexane which would be the correct management if sticky blood were also present.

As for your children - hopefully medicine will have shed more light on unlocking more of the secrets hidden within PE to control it before you become a grandma!

Warm wishes
Liz

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